Weekly Research Updates & Guidance
Please check this page regularly for guidance and research updates.
Last updated: 1/13/25
NIH General Announcements and Notices of Special Interest
(NOT-AG-24-097)
National Institute on Aging
This Notice informs potential applicants that the National Institute on Aging (NIA) will hold a pre-application technical assistance webinar regarding potential applications in response to Notice of Funding Opportunity (NOFO) RFA-AG-25-001, “Deriving Common Data Elements from Real-World Data for Alzheimer’s Disease (AD) and AD-Related Dementias (ADRD) (U24 Clinical Trial Not Allowed).”
When: January 8, 2025
Where: Virtual event; register here. Webinar connection information will be provided to registered participants
Time: 12:30 PM to 1:30 PM Eastern Time
(NOT-EB-24-021)
National Institute of Biomedical Imaging and Bioengineering
The purpose of this Notice is to inform potential applicants that effective December 31, 2024, the National Institute of Biomedical Imaging and Bioengineering (NIBIB) will participate in RFA-EY-25-001, "BRAIN Initiative: New Concepts and Early-Stage Research for Recording and Modulation in the Nervous System (R21) (Clinical Trial Not Allowed)", issued by the National Institutes of Health.
(NOT-GM-25-018)
National Institute of General Medical Sciences
The purpose of this Notice is update the date of the virtual question and answer office hour for prospective applicants who plan to submit applications to the following programs:
National Institute of General Medical Sciences Predoctoral Basic Biomedical Sciences Research Training Program (PAR-23-228)
Medical Scientist Training Program (MSTP) (PAR-24-128)
Leading Equity and Diversity in the Medical Scientist Training Program (LEAD MSTP) (PAR-23-030)
Due to the Federal holiday on January 9, 2025, the office hour will now be held on January 13, 2025 from 1:00 - 2:30 pm ET.
Question & Answer Office Hour Information
Date: Monday, January 13, 2025
Time: 1:00 - 2:30 pm, Eastern Time (ET)
Request for Information on the National Institute on Aging Health Disparities Research Framework
(NOT-AG-24-086)
National Institute on Aging
This Request for Information (RFI) invites feedback on topics the National Institute on Aging (NIA) should consider as it prepares to revise and update the NIA Health Disparities Research Framework (the Framework). NIA intends to publish a revised version of the Framework in 2025.
(NOT-MH-25-055)
National Institute of Mental Health
The purpose of this Notice is to update the National Institute of Mental Health (NIMH) expectations for collection of Common Data Elements (CDEs) for mental health human subjects research supported by the NIMH. Unless NIMH stipulates otherwise during the negotiation of the terms and conditions of an award, this Notice applies to all grant applications involving human research participants submitted on or after April 1, 2025. NOT-MH-20-067 and NOT-MH-23-105 will be enforced for applications submitted on or before March 31, 2025.
(NOT-AG-24-094)
National Institute on Aging
This Notice informs that, effective as of the Release Date stated above, the National Institute on Aging (NIA) is participating in Notice of Funding Opportunity (NOFO) RFA-NR-25-003, “Transformative Research to Address Health Disparities and Advance Health Equity (U01 Clinical Trial Optional).”
NIH Operates Under a Continuing Resolution
(NOT-OD-25-054) National Institutes of Health
The Department of Health and Human Services (HHS), including National Institutes of Health (NIH), operates under the American Relief Act, 2025 (Public Law 118-84) signed by President Biden on December 21, 2024. This Act (CR) continues government operations through March 14, 2025, at the Fiscal Year (FY) 2024 enacted level, with no reduction.
(NOT-PM-25-002)
Office of the Director, NIH
The National Institutes of Health is issuing this Notice to alert the community about an upcoming Research Opportunity Announcement (ROA) from the All of Us Research Program, a historic effort to gather data from more than 1 million people who reflect the diversity of the United States and its territories, with the goal of accelerating health research and medical breakthroughs, and enabling individualized prevention, treatment, and care. The purpose of the upcoming ROA is to solicit proposals from potential partners to support communications, marketing, and user experience activities for the All of Us Research Program, which are central to the vast majority of program goals, initiatives, and partners.
(NOT-AG-24-030)
National Institute on Aging
Tremendous strides have been made in recent years in the study of the clinical neurobiology of Alzheimer’s disease (AD) and AD-related dementias (ADRD). Biomarkers play a key role in understanding AD/ADRD and are crucial to translating basic neuroscience research into clinical settings. Biomarkers have become essential components in trials of disease-modifying therapies for AD. This NOSI encourages research applications that develop and apply novel biomarkers to characterize and diagnose AD/ADRD.
(NOT-AG-24-042)
National Institute on Aging
This Notice of Special Interest (NOSI) encourages investigator-initiated research on all aspects of cognitive epidemiology relevant to Alzheimer's disease (AD) and AD-related dementias (ADRD) and cognitive resilience, and identifies specific areas that build on current efforts supported by NIA as well as gaps and opportunities identified in the 2018 and 2021 Alzheimer’s Disease Research Summits. This NOSI is a reissue of NOT-AG-21-045.
(NOT-AG-24-042)
National Institute on Aging
This Notice of Special Interest (NOSI) encourages investigator-initiated research on all aspects of cognitive epidemiology relevant to Alzheimer's disease (AD) and AD-related dementias (ADRD) and cognitive resilience, and identifies specific areas that build on current efforts supported by NIA as well as gaps and opportunities identified in the 2018 and 2021 Alzheimer’s Disease Research Summits. This NOSI is a reissue of NOT-AG-21-045.
(NOT-OD-25-042)
Office of the Director, NIH
The Environmental influences on Child Health Outcomes (ECHO) Program’s mission is to enhance the health of children for generations to come through collaborative research that informs programs, policy, or practice. Inclusion of many perspectives can help ECHO achieve this goal by fostering scientific innovation, improving the quality of the research, and enhancing public trust. As such, the ECHO Program is committed to supporting a diverse biomedical research workforce, including individuals from groups identified in NOT-OD-20-031 - Notice of NIH’s Interest in Diversity as underrepresented in the biomedical, clinical, behavioral and social sciences.
NSF – National Science Foundation General Announcements
DEB Virtual Office Hour: Partnership to Advance Conservation Science and Practice (PACSP)
Our next Virtual Office Hour, on January 13th from 1pm-2pm Eastern Time, will focus on The Partnership to Advance Conservation Science and Practice (PACSP) funding opportunity. Representatives from the programs will be present to answer questions. Use the registration link below to set up your participation in any of our upcoming DEB Virtual Office Hours.
CISE Research Expansion (NSF-536) Office Hours
Tuesday, January 14, 2025, 1:00 p.m. – 2:00 p.m.
The CISE Research Expansion Team will offer office hours, designed to answer questions from all potential applicants. Potential PIs from eligible Institutions and Co-PIs from all Institutions with established efforts in any of the sub-fields of the program are encouraged to participate.
NSF Opportunities Introduction & Listening Session
Tuesday, January 14, 2025, 3:00 p.m. – 5:00 p.m.
Join the U.S. National Science Foundation Directorate for STEM Education (EDU) to learn about EDU funding opportunities. EDU program representatives will introduce funding opportunities and invite questions. They will then open the floor to discussion about ideas and challenges associated with acquiring NSF funding. This information is especially helpful to institutions in EPSCoR Jurisdictions.
Decision, Risk and Management Sciences Office Hour
Wednesday, January 15, 2025, 2:00 p.m. – 3:00 p.m.
Please join the Decision Risk Management Sciences Program to discuss questions about the program with the program directors.
Ethical and Responsible Research Program Office Hours
Wednesday, January 15, 2025, 3:00 p.m. – 4:00 p.m.
Please join the Ethical and Responsible Research Program (ER2) to discuss questions about the program with the program director(s).
Office Hours: Intro to America’s Seed Fund at NSF
Thursday, January 16, 2025, 2:00 p.m. – 3:00 p.m.
America’s Seed Fund, powered by the U.S. National Science Foundation,
focuses on transforming scientific and engineering discoveries into products and services with commercial and societal impact. Each year, NSF awards $230+ million in research and development (R&D) funding to about 400 startups across the United States. We invite you to attend a virtual question and answer session titled Office Hours: Intro to America’s Seed Fund at NSF.
In this session, an NSF Small Business Innovation Research/Small Business Technology Transfer (SBIR/STTR) program director will answer questions about how to get started, the basics of eligibility, and what we look for when we review Project Pitches.
Register for the Intro to America's Seed Fund webinar on Zoom.
Department of Defense (DOD)
Fiscal Year 2025 (FY25) pre-announcements for Department of Defense (DOD) programs managed by the Congressionally Directed Medical Research Programs (CDMRP).
The FY25 Defense Appropriations Bill has not been signed into law. The CDMRP is unable to release new funding opportunities under the current Continuing Resolution. The CDMRP is providing pre-announcement information to allow investigators time to plan and develop ideas for submission to anticipated funding opportunities should CDMRP receive FY25 appropriations. Pre-announcements should not be construed as an obligation or promise by the government. Once funding is available, CDMRP funding opportunities will be posted on the Grants.gov website. Pre-application and application deadlines will be available when opportunities are released, contingent upon future funding.
FY25 Pre-announcements released:
The Amyotrophic Lateral Sclerosis Research Program (ALSRP) released a pre-announcement for the following funding opportunities:
- Pilot Clinical Trial Award
- Clinical Outcomes and Biomarkers Award
- Therapeutic Development Award
- Therapeutic Idea Award
To view the pre-announcement, visit https://cdmrp.health.mil/pubs/press/2025/25alsrppreann
The Autism Research Program (ARP) released a pre-announcement for the following funding opportunities:
- Career Development Award
- Clinical Trial Award
- Discovery Award
- Idea Development Award
To view the pre-announcement, visit https://cdmrp.health.mil/pubs/press/2025/25arppreann
The Ovarian Cancer Research Program (OCRP) released a pre-announcement for the following funding opportunities:
- Pilot Award
- Investigator-Initiated Research Award
- Ovarian Cancer Academy – Early-Career Investigator Award
- Ovarian Cancer Clinical Trial Academy – Early-Career Investigator Award
- Clinical Trial Translational Endpoints Award
- Clinical Trial Award
To view the pre-announcement, visit https://cdmrp.health.mil/pubs/press/2025/25ocrppreann
The Tuberous Sclerosis Complex Research Program (TSCRP) released a pre-announcement for the following funding opportunities:
- Clinical Translational Research Award
- Exploration – Hypothesis Development Award
- Idea Development Award
To view the pre-announcement, visit https://cdmrp.health.mil/pubs/press/2025/25tscrppreann
The Vision Research Program (VRP) released a pre-announcement for the following funding opportunity:
- Mentored Clinical Research Award
To view the pre-announcement, visit https://cdmrp.health.mil/pubs/press/2025/25vrppreann
The VRP anticipates releasing a pre-announcement for additional funding opportunities in March 2025.
Fiscal Year 2025 (FY25) pre-announcements for Department of Defense (DOD) programs managed by the Congressionally Directed Medical Research Programs (CDMRP).
The FY25 Defense Appropriations Bill has not been signed into law. The CDMRP is unable to release new funding opportunities under the current Continuing Resolution. The CDMRP is providing pre-announcement information to allow investigators time to plan and develop ideas for submission to anticipated funding opportunities should CDMRP receive FY25 appropriations. Pre-announcements should not be construed as an obligation or promise by the government. Once funding is available, CDMRP funding opportunities will be posted on the Grants.gov website. Pre-application and application deadlines will be available when opportunities are released, contingent upon future funding.
FY25 Pre-announcements released:
The Epilepsy Research Program (ERP) released a pre-announcement for the following funding opportunities:
- Idea Development Award
- Leveraging Research Award
- Research Partnership Award
- Virtual Post-Traumatic Epilepsy Research Center Faculty Award
To view the pre-announcement visit https://cdmrp.health.mil/pubs/press/2025/25erppreann
Fiscal Year 2025 (FY25) pre-announcements for Department of Defense (DOD) programs managed by the Congressionally Directed Medical Research Programs (CDMRP).
The FY25 Defense Appropriations Bill has not been signed into law. The CDMRP is unable to release new funding opportunities under the current Continuing Resolution. The CDMRP is providing pre-announcement information to allow investigators time to plan and develop ideas for submission to anticipated funding opportunities should CDMRP receive FY25 appropriations. Pre-announcements should not be construed as an obligation or promise by the government. Once funding is available, CDMRP funding opportunities will be posted on the Grants.gov website. Pre-application and application deadlines will be available when opportunities are released, contingent upon future funding.
FY25 Pre-announcements released:
The Epilepsy Research Program (ERP) released a pre-announcement for the following funding opportunities:
- Idea Development Award
- Leveraging Research Award
- Research Partnership Award
- Virtual Post-Traumatic Epilepsy Research Center Faculty Award
To view the pre-announcement visit https://cdmrp.health.mil/pubs/press/2025/25erppreann
BrightFocus Foundation
American Heart Association
Ralph L. Sacco Scholarships in Brain Health
Proposal deadline: Thursday, January 30, 2025
Jointly funded by the American Academy of Neurology and the American Heart Association/American Stroke Association, with funds from a generous bequest by Dr. Ralph L. Sacco, this program enables early career trainees to undertake a mentored two-year research project targeting various aspects of brain health. The 2025 awards are for MD or PhD (or equivalent doctoral degree) applicants in postdoctoral fellowship training with a focus on brain health as of July 1, 2025. Projects for this cycle must focus on prevention.
International Visiting Professorship Award
Applications due: Tuesday, February 4, 2025
Novel pilot program to bring internationally based scientists to the U.S. for one week to foster scientific exchange -- to expand research experiences and collaborative opportunities for the awarded Visiting Professor and their U.S.-based host in research that aligns with the AHA mission.
Proposal deadline: Wednesday, February 5, 2025
For early and mid-career investigators proposing innovative implementation science studies that align with AHA’s mission and provide optimal approaches to improving public health. Implementation science uses evidence-based theories and frameworks to identify strategies that facilitate the uptake of evidence to improve health. Implementation science studies can use qualitative studies, mixed-methods, quasi-experimental designs, randomized controlled trials, and community-based participatory research.
Career Development Award
Research Supplement to Promote Diversity in Science
Proposal deadline: Thursday, February 6, 2025
To enable current AHA awardees to identify and serve as mentors for predoctoral and postdoctoral fellows from underrepresented groups in science and medicine.
Transformational Project Award
Thursday, February 13, 2025
Supports highly innovative, high-impact projects that build on work in progress that could ultimately lead to critical discoveries or major advancements that will accelerate the field of cardiovascular and/or cerebrovascular research. Research deemed innovative may be built around an emerging paradigm, approaching an existing problem from a new perspective, or exhibit other uniquely creative qualities.
PCORI – Patient Centered Outcomes Research Institute
