Dysregulation of the Excitation/Inhibition Ratio in a Mouse Model of Schizophrenia

In this proposal, we will investigate how the E/I ratio is altered across the 24h day in a mouse model of schizophrenia. We hypothesize that the normal oscillation of the E/I ratio will be dysregulated (i.e. flattened or shifted in time, patterns that we have observed in our preliminary studies of autism spectrum disorder model mice), resulting in a mismatch between the E/I ratio and appropriate behavioral states. 

To this end, we will develop an innovative approach to track the E/I ratio longitudinally in vivo, then implement this strategy in the Relnrl/+ mouse model of schizophrenia.