Psychosocial Stress-Induced Vascular Contributions to Cognitive Impairment and Alzheimer’s Disease: The Role of Xanthine Oxidase

Chronic psychosocial stress is a major risk factor that contributes to the vascular contributions to cognitive impairment and dementia. The purpose of this project is to determine the mechanisms by which chronic stress contributed to cerebrovascular dysfunction and cognitive decline, and their relationship with Alzheimer’s disease, with a focus on the mechanistic role of xanthine oxidase.