Targeting Protein Glutamylation in Blinding Diseases

Modification of proteins by small chemical moieties can profoundly change their properties and affect the function of the cell. Our research focuses on one such modification called protein glutamylation, which involves adding or removing glutamate residues from proteins.

This process is crucial because dysregulated protein glutamylation, including excessive glutamylation, is known to cause human blindness. Therefore, our larger goal is to understand how protein glutamylation impacts vision.